Oxidants and antioxidants: friends or foes?
نویسندگان
چکیده
Albeit the existence of ‘free radicals’ having been known for a considerable time within the sphere of chemistry, these interesting kinds of oxidizing molecules attracted the attention of medical scientists and physicians during the early 1950s when Denham Harman started to publish a number of reports on the “free radical theory of aging” [1]. Two decades later, grounded in the recognition that free radical production in the cell occurs mainly in the mitochondria and that mutations of the mitochondrial DNA (mtDNA) are strongly involved in the aging process, this theory evolved into the “mitochondrial theory of aging” [2, 3]. Despite the ‘theory’ label, the entire medical world believes, at least in part, in the truth of this explanation for the underlying mechanisms of the unavoidable biological process aging.
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عنوان ژورنال:
دوره 1 شماره
صفحات -
تاریخ انتشار 2012